1. To cause irritation or deep bitterness.
2. To fester.

… Left out of the discussion over the years have been people like Trump’s voters, who coincidentally took the first hit along the way in the form of lowered middle-class wages and benefits. They were also never told that things they cared about, like their national identity as Americans, were to have diluted meaning in the more borderless future. This is why the “basket of deplorables” comment rankled so badly. It’s not like it was anywhere near as demeaning or vicious as any of 10,000 Trump insults. But it spoke to a factual disconnnect.

From the post: Win or lose, Donald Trump has forever changed the American political system
Source: The Fury and Failure of Donald Trump (rollingstone.com)